No trains will be able to enter or leave King's Cross station on Saturday and Sunday.
Network Rail will work on testing signalling equipment and install new overhead line equipment.
Gas distributor Cadent will be working on 770 metres of gas mains under Barrowby Road.
LNER trains will be restricted to 50mph as high winds are forecast for the region.
The new crossing on Harlaxton Road in Grantham will be outside the Premier Inn near the junction with the A1.
Read what Lincolnshire County Council have been doing to keep roads safe during winter.
With just 164 people using the station last year, this station has been listed in the UK’s top 10 least used.
Trains from Grantham to London face disruption this weekend due to £1.2 billion upgrades.
Roadwork have been completed in Grantham town centre to repair road humps.
A South Witham resident has branded the village's pothole-ridden roads as "a disgrace".
Nurse furious that pothole has not been repaired since her car was damaged on December 23.
Network Rail has replaced 2.4 miles of track, using a specialist train called the Track Renewal System.